Crystal Structure of the Membrane-bound Bifunctional Transglycosylase PBP1b from Escherichia Coli
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چکیده
In the last decade, the prevalence and occasional outbreaks of drug-resistant bacteria, such as methicillinresistant Staphylococcus aureus (MRSA) and vancomycinresistant enterococci (VRE), have posed appalling hurdles in the treatment of bacterial infections. New antibacterial agents are, as a result, in desperate demand to combat these pernicious antibiotic-resistant problems that can otherwise cause life-or-death struggles.
منابع مشابه
Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli.
Drug-resistant bacteria have caused serious medical problems in recent years, and the need for new antibacterial agents is undisputed. Transglycosylase, a multidomain membrane protein essential for cell wall synthesis, is an excellent target for the development of new antibiotics. Here, we determined the X-ray crystal structure of the bifunctional transglycosylase penicillin-binding protein 1b ...
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